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KMID : 0356620070220060440
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Journal of Korean Society of Endocrinology
2007 Volume.22 No. 6 p.440 ~ p.445
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A Case of Epithelioid Hemangioendothelioma of the Pelvic Retroperitoneum with Hypoglycemia
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Kim Ji-Ryang
Jeon Young-Jae
Park Kee-Tae
Kang Yang-Ho
Son Suk-Man
Kim In-Ju
Kim Yong-Gi
Choi Kyung-Un
Lee Kwang-Jae
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Abstract
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Hypoglycemia caused by a non-islet cell tumor (NICT) is a rare condition. The mechanism of NICT-induced hypoglycemia is still unclear, but insulin-like growth factor-II (IGF-II) has been thought to play a major role in its development. NICT is usually of mesenchymal or epithelial cell origin, but reports on NICT of an endothelial cell origin, which causes hypoglycemia, have yet to surface. Here, we report on a case of a 63-year-old female patient who was diagnosed with epithelioid hemangioendothelioma-induced hypoglycemia. Epithelioid hemangioendothelioma is a borderline malignant vascular tumor that is of endothelial cell origin and usually occurs in soft tissue, skin, lung, and liver. It was observed that serum insulin, C-peptide, and IGF-I were reduced, but the IGF-II level was elevated in hypoglycemia. The PET-CT showed no abnormal glucose metabolism in the tumor. Dextrose fluid was administered to the patient to control hypoglycemia until the operation. For treatment and diagnosis, surgical resection of the tumor and total hysterectomy were performed. The specimen was noted to have epithelioid hemangioendothelioma. Hypoglycemia-related symptoms disappeared after surgical resection was performed. (J Kor Endocr Soc 22:440~445, 2007)
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KEYWORD
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epithelioid hemangioendothelioma, hypoglycemia, insulin-Like growth factor-2
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